CXCR 3 ( chemokine ( C - X - C motif ) receptor 3 ) Makoto
نویسندگان
چکیده
Other names: CD182; CD183; CKR-L2; CMKAR3; CXC-R3; CXCR-3; GPR9; IP10; IP10-R; Mig-R; MigR HGNC (Hugo): CXCR3 Location: Xq13.1 Note: CXCR3 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (CXCL10), Mig (CXCL9) and I-TAC (CXCL11). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Binding of chemo-kines to CXCR3 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. A hallmark of CXCR3 is its prominent expression in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflame-matory lesions, suggesting that CXCR3 and its chemokines participate in the recruitment of infla-mematory cells. DNA/RNA
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